منابع مشابه
An Updated View of Translocator Protein (TSPO)
Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respi...
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Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cAMP signal to the catalysis of guanine exchange in the Rap substrate. In the present paper, we review the NMR studies that we have undertaken on the CBD (cyclic-nucleotide-binding domain) of Epac1. Our NMR investigations have shown that cAMP controls distal autoinhibitory interacti...
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The recent development in oil and gas industry increases the production and consumption of oil. The enormous amount of oily wastewater produced is urged to be treated to prevent humanity and environment from being threatened. Membrane technology is an appealing alternative for oily wastewater treatment due to its design simplicity, energy efficiency and environmentally benign approach. In this ...
متن کاملProtein dynamics detected in a membrane-embedded potassium channel using two-dimensional solid-state NMR spectroscopy.
We report longitudinal (15)N relaxation rates derived from two-dimensional ((15)N, (13)C) chemical shift correlation experiments obtained under magic angle spinning for the potassium channel KcsA-Kv1.3 reconstituted in multilamellar vesicles. Thus, we demonstrate that solid-state NMR can be used to probe residue-specific backbone dynamics in a membrane-embedded protein. Enhanced backbone mobili...
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Membrane proteins play key roles in biology. Determination of their structure in a membrane environment, however, is highly challenging. To address this challenge, we developed an approach that couples hydrogen/deuterium exchange of membrane proteins to rapid unfolding and detection by solution-state NMR spectroscopy. We show that the method allows analysis of the solvent protection of single r...
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ژورنال
عنوان ژورنال: European Biophysics Journal
سال: 2020
ISSN: 0175-7571,1432-1017
DOI: 10.1007/s00249-020-01487-0